Cumulative relapse probability for the MOG positive group at 1 year was 0.428 and at 4 years was 0.628. Onset was moderate-severe in 64%, but 74% had good response to initial steroid therapy. Most common onset phenotypes were optic neuritis (23, 55% 8 bilateral) and myelitis (9, 21% 6 longitudinally extensive) Three of the patients in our cohort experienced cortical encephalitis two presented with seizures. Of 42 patients (27 female), median disease onset age was 29 years (range 3–62 9 pediatric cases), 20 (47%) were non-Caucasian, and 3 (7%) had comorbid autoimmune disease. Twenty additional MOG positive cases were identified prospectively. One multiple sclerosis (MS) control serum was MOG seropositive. Results: Retrospective testing identified 21 MOG seropositives (14 by live assay only, 3 by fixed assay only and 4 by both) representing 14% of the “NMOSD suspects” cohort. Clinical data was reviewed retrospectively. Additional MOG seropositive cases were identified through routine clinical interaction (2016–2018) using one of these laboratories. Methods: AQP4-antibody seronegative patients presenting 2005–2016 with CNS inflammatory disease suspicious for NMOSD, as well as 20 MS controls, were retrospectively tested for MOG-IgG1 antibodies by live cell-based assay at Oxford Autoimmune Neurology Diagnostic Laboratory (UK) and by a commercial fixed cell-based assay at MitogenDx (Calgary, Canada).
We describe a multi-ethnic population with MOG antibody seropositivity from the University of British Columbia MS/NMO clinic. NMOSD seronegative patients, and those with limited forms of the disorder, become suspects for MOG antibody-associated disease.
Introduction: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease is a recently described central nervous system (CNS) inflammatory disorder with phenotypic overlap with Neuromyelitis Optica Spectrum Disorder (NMOSD).
1UBC MS/NMO Clinic, University of British Columbia, Vancouver, BC, Canada.Helen Cross 1 Farahna Sabiq 1 Nathalie Ackermans 2 Andrew Mattar 1 Shelly Au 1 Mark Woodhall 3 Bo Sun 3 Virginia Devonshire 1 Robert Carruthers 1 Ana Luiza Sayao 1 Virender Bhan 1 Alice Schabas 1 Jillian Chan 1 Marvin Fritzler 4 Patrick Waters 3 Anthony Traboulsee 1 *
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